At Core iV Therapy®, we don’t believe in random wellness.
We believe in strategic stacking—using the right therapies, in the right order, for the right reason.
This is an update to our original stacking philosophy (read it here): the base stack now runs five layers deep, and it always follows the same shape.
Every stack we build starts the same way and ends the same way:
- 👉 Ozone always goes first
- 👉 Hyperbaric Oxygen Therapy (HBOT) always goes last
What changes in between depends on the goal — but the layers we pull from are Peptides, NAD & Niagen NR, and Exosomes.
Why Order Matters
The body responds better when therapies are layered intentionally. Here’s the logic behind the sequence, start to finish.
1. Ozone First → Prep & Optimize
We always start with ozone therapy because it may help:
- Improve oxygen utilization
- Support detox pathways
- Reduce inflammatory burden
- Enhance circulation
👉 Think of this as preparing the terrain.
2. Peptides Second → Direct Repair
Once inflammation and oxidative stress are addressed, peptides help:
- Signal tissue repair
- Support gut and immune function
- Enhance recovery pathways
- Improve communication between systems
👉 This gives the body direction.
3. NAD + Niagen NR Third → Fuel & Sustain Energy
NAD helps support cellular energy production, brain function, and mitochondrial health — and it works quickly because it’s delivered directly into the body.
Niagen NR (nicotinamide riboside) is a precursor to NAD. Instead of delivering NAD directly, it helps the body build and maintain NAD levels over time.
👉 NAD IV → immediate boost
👉 Niagen NR IV → longer-lasting support
Together, they cover both the short game and the long game.
4. Exosomes Fourth → Deliver the Message
By this point in the stack, circulation is optimized and repair signals are already in motion. That’s exactly the environment exosome therapy needs to do its job.
Exosomes are cellular messengers — and a message is only as useful as the environment it lands in. Layering them in after ozone, peptides, and NAD/Niagen means the signals exosomes carry have a well-oxygenated, well-circulated system ready to receive them.
👉 This is where the message gets delivered.
5. HBOT Last → Amplify & Seal It In
We finish every stack with Hyperbaric Oxygen Therapy. After everything else has prepped, directed, fueled, and messaged the body, HBOT floods the system with oxygen — supporting the repair and recovery processes already set in motion by the rest of the stack.
👉 Think of HBOT as sealing in everything that came before it.
🔥 STACKING PROTOCOL EXAMPLES
Here’s what the full Ozone → Peptides → NAD/Niagen → Exosomes → HBOT stack looks like when it’s built around a specific goal.
🏃 Athletic Performance & Recovery Protocol™
Best For:
- Athletes in-season or training hard
- Post-injury recovery
- Clients chasing faster turnaround between workouts
Protocol Example
- Ozone (MAH or High-Dose) → weekly
- Recovery-focused peptide stack → 3–5x weekly
- NAD IV (250–500mg) → weekly
- Niagen NR IV → between NAD sessions
- Exosome therapy → 1–2x monthly
- HBOT → 2–3x weekly, especially around training or competition
Goals
✔ Faster recovery between sessions
✔ Reduced inflammation and soreness
✔ Sustained energy
✔ Support for tissue repair
🧬 Anti-Aging & Longevity Protocol™
Best For:
- Clients focused on healthy aging
- Advanced biohackers
- Anyone building a long-term longevity routine
Protocol Example
- Ozone (EBOO or High-Dose) → weekly or biweekly
- Longevity-focused peptide stack → daily or cycled
- NAD IV (500–750mg) → weekly
- Niagen NR IV → layered between NAD sessions
- Exosome therapy → monthly
- HBOT → weekly
Goals
✔ Cellular optimization
✔ Support for healthy aging pathways
✔ Sustained energy and cognitive performance
✔ Long-term resilience
🩹 Inflammation & Gut Health Protocol™
Best For:
- Mild to moderate inflammation
- Gut-related issues
- Beginners to biohacking who want to start light
Protocol Example
- Ozone (MAH or insufflation) → weekly
- Targeted gut/immune peptides → 3–5x weekly
- Niagen NR IV or oral support → weekly
- Exosome therapy → monthly
- HBOT → 1–2x weekly
Goals
✔ Reduced inflammation
✔ Support for gut and immune health
✔ Improved recovery and resilience
🛡️ Immune & Resilience Protocol™
Best For:
- Clients who get run down easily
- Support during high-stress seasons
- Anyone rebuilding after illness or burnout
Protocol Example
- Ozone (High-Dose or UBI) → weekly
- Immune-support peptide stack → 3–5x weekly
- NAD IV (250–500mg) → biweekly
- Niagen NR IV → between NAD sessions
- Exosome therapy → monthly
- HBOT → weekly
Goals
✔ Stronger immune resilience
✔ Reduced downtime
✔ Steadier energy through demanding periods
The Bigger Picture
Most places offer isolated treatments.
At Core iV Therapy®, we build:
👉 structured longevity and performance systems
Because the goal isn’t temporary energy, temporary relief, or chasing whatever wellness trend is popular this month.
The goal is:
👉 creating a body that performs better, recovers faster, and sustains energy long-term.
Quick Answers: Stacking Therapies at Core iV
What order should I stack IV and wellness therapies in?
At Core iV Therapy, we always start with Ozone and finish with Hyperbaric Oxygen Therapy (HBOT), layering Peptides, NAD + Niagen NR, and Exosomes in between based on your specific goals.
Do I need to do the full 5-step stack every visit?
No. Many clients build toward the full stack gradually, or focus on two to three layers that match their current goal, such as recovery or energy support. Our team can help you decide where to start.
Can all five therapies be done in one visit?
It depends on the protocol and your schedule. Some clients combine several layers in one visit, while others space sessions across the week — our team can help you plan a realistic cadence.
Call to Action
Interested in building your own customized stack?
👉 Call Core iV Therapy® at 866-426-7348 or visit us at 108 Elden Street, Suite 15A, Herndon, VA 20170 to schedule your consultation.